Allantoin is a synthetic free-flowing hygroscopic powder widely used in cosmetic, dermatological and pharmaceutical formulations for its soothing and anti-irritating properties. Allantoin has a moisturizing and keratolytic effect, increasing the water content of the extracellular matrix and enhancing the desquamation of upper layers of dead skin cells, increasing the smoothness of the skin; promoting cell proliferation and wound healing; and a soothing, anti-irritant, and skin protectant effect by forming complexes with irritants and sensitizing agents. Allantoin stimulates healthy, normal tissue formation even at low concentrations.
While allantoin is present in botanical extracts of the comfrey plant, it is generally chemically synthesized to meet worldwide demand. It is non-toxic, non-irritating, and non-allergenic.